https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53713 Wed 28 Feb 2024 16:37:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51417 Wed 28 Feb 2024 16:32:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52762 Wed 28 Feb 2024 16:23:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53333 1 s and MTT>145%. Delay time (DT) best estimated the infarct core (AUC = 0.74). The optimal core threshold was a DT >1.5 s. The voxel-based analyses indicated CTP was most accurate in the calcarine (Penumbra-AUC = 0.75, Core-AUC = 0.79) and cerebellar regions (Penumbra-AUC = 0.65, Core-AUC = 0.79). For the volume-based analyses, MTT >160% demonstrated best correlation and smallest mean-volume difference between the penumbral estimate and follow-up MRI (R2 = 0.71). MTT >170% resulted in the smallest mean-volume difference between the core estimate and follow-up MRI, but with poor correlation (R2 = 0.11). Conclusion: CTP has promising diagnostic utility in POCI. Accuracy of CTP varies by brain region. Optimal thresholds to define penumbra were DT >1 s and MTT >145%. The optimal threshold for core was a DT >1.5 s. However, CTP core volume estimates should be interpreted with caution.]]> Wed 28 Feb 2024 16:20:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53434 Wed 28 Feb 2024 15:37:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50530 Wed 28 Feb 2024 15:35:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52589 Wed 28 Feb 2024 15:29:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50453 Wed 28 Feb 2024 15:13:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53856 Wed 28 Feb 2024 15:05:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45551 Wed 28 Feb 2024 14:47:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52055 Wed 27 Sep 2023 15:30:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52058 Wed 27 Sep 2023 15:29:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52051 Wed 27 Sep 2023 15:28:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50471 Wed 26 Jul 2023 15:35:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50458 Wed 26 Jul 2023 13:35:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52740 Wed 25 Oct 2023 08:47:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52470 Wed 24 Apr 2024 11:47:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55374 Wed 22 May 2024 15:07:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55329 Wed 15 May 2024 15:47:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52191 Wed 15 May 2024 15:47:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53573 Wed 15 May 2024 15:05:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54272 Wed 13 Mar 2024 19:06:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54787 Wed 13 Mar 2024 08:39:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52419 Wed 11 Oct 2023 12:06:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52409 Wed 11 Oct 2023 11:58:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52406 Wed 11 Oct 2023 11:51:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53235 Wed 10 Apr 2024 15:56:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54659 Wed 10 Apr 2024 09:45:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51517 90% accuracy at 0.1 m resolution. At the study site, saltmarsh colonised most suitable areas, increasing by 142% and resulting in 56 tonnes of carbon sequestered, within a 4-year period, providing insight into blue carbon regeneration trajectories. Saltmarsh growth patterns were species-specific, influenced by species’ reproductive and dispersal strategies. Our findings suggested that biotic factors and interactions were important in influencing species’ distributions and succession trajectories. This work can help improve the efficiency and effectiveness of restoration planning and monitoring at coastal wetlands and similar ecosystems worldwide, with the potential to apply this approach to other types of remote sensing imagery and to calculate other rehabilitation co-benefits. Importantly, the method can be used to calculate blue carbon habitat creation following tidal restoration of coastal wetlands.]]> Wed 07 Feb 2024 14:42:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52680 Wed 07 Feb 2024 14:41:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51460 Wed 06 Sep 2023 08:36:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52901 Tue 31 Oct 2023 15:52:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54479 Tue 27 Feb 2024 15:03:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54448 Tue 27 Feb 2024 14:02:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54408 Tue 27 Feb 2024 13:50:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45298 6 million deaths globally at the time of writing. COVID-19, instigated by the SARS - coronavirus-2 (SARS-CoV-2), causes unprecedented challenges in all facets of our lives, and never before brought scientists of all fields together to focus on this singular topic. While for the past 50 years research have been heavily focused on viruses themselves, we now understand that the host immune responses are just as important in determining the pathogenesis and outcomes of infection. Research in innate immune mechanisms is crucial in understanding all aspects of host antiviral programmes and the mechanisms underpinning virus-host interactions, which can be translated to the development of effective therapeutic avenues. This review summarizes what is known and what remains to be explored in the innate immune responses to influenza viruses and SARS-CoVs, and virus-host interactions in driving disease pathogenesis. This hopefully will encourage discussions and research on the unanswered questions, new paradigms, and antiviral strategies against these emerging infectious pathogens before the next pandemic occurs.]]> Tue 23 May 2023 08:41:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53311 Tue 21 Nov 2023 12:01:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53296 Tue 21 Nov 2023 11:54:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48543 Tue 21 Mar 2023 15:42:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54369 Tue 20 Feb 2024 19:56:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54870 Tue 19 Mar 2024 15:57:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52584 Tue 17 Oct 2023 15:56:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52582 Tue 17 Oct 2023 15:55:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52572 Tue 17 Oct 2023 15:47:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52565 Tue 17 Oct 2023 15:40:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52760 Tue 14 Nov 2023 15:32:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48281 Tue 14 Mar 2023 10:51:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54247 Tue 13 Feb 2024 13:19:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51612 Tue 12 Sep 2023 13:50:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51603 Tue 12 Sep 2023 13:35:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51602 Tue 12 Sep 2023 13:35:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53624 2 years. Information about demographics, bite circumstances, species involved, clinical and laboratory features of envenoming, and treatment is collected and entered into a purpose-built database. Results: Between January 2002 and August 2020, 13 patients with suspected sea snake bite were recruited to ASP, 11 were male; median age was 30 years. Bites occurred in Queensland and Western Australia. All patients were in or around, coastal waters at the time of bite. The species involved was identified in two cases (both Hydrophis zweifeli). Local effects occurred in 9 patients: pain (5), swelling (5), bleeding (2), bruising (1). Envenoming occurred in eight patients and was characterised by non-specific systemic features (6) and myotoxicity (2). Myotoxicity was severe (peak CK 28200 and 48100 U/L) and rapid in onset (time to peak CK 13.5 and 15.1 h) in these two patients. Non-specific systemic features included nausea (6), headache (6), abdominal pain (3), and diaphoresis (2). Leukocytosis, neutrophilia, and lymphopenia occurred in both patients with myotoxicity and was evident on the first blood test. No patients developed neurotoxicity or coagulopathy. Early Seqirus antivenom therapy was associated with a lower peak creatine kinase. Conclusion: While relatively rare, sea snake envenoming is associated with significant morbidity and risk of mortality. Early antivenom appears to have a role in preventing severe myotoxicity and should be a goal of therapy.]]> Tue 12 Dec 2023 15:26:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53012 Tue 07 Nov 2023 08:45:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55498 Tue 04 Jun 2024 20:56:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55497 Tue 04 Jun 2024 20:55:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45550 Tue 01 Nov 2022 10:56:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45401 Thu 27 Oct 2022 17:29:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44824 Thu 27 Oct 2022 12:44:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50515 Thu 27 Jul 2023 14:34:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50496 Thu 27 Jul 2023 10:44:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54004 Thu 25 Jan 2024 13:52:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52638 Thu 19 Oct 2023 15:12:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52625 Thu 19 Oct 2023 15:04:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55129 Thu 11 Apr 2024 11:14:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51481 Thu 07 Sep 2023 10:51:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51474 Thu 07 Sep 2023 10:44:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50738 Thu 03 Aug 2023 16:40:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50631 Mon 31 Jul 2023 15:53:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54032 Mon 29 Jan 2024 13:32:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54977 Mon 25 Mar 2024 15:20:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52708 Mon 23 Oct 2023 16:11:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52501 Mon 16 Oct 2023 10:10:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51810 Mon 13 May 2024 12:42:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51350 Mon 13 May 2024 12:41:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53620 Mon 13 May 2024 12:39:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54767 Mon 11 Mar 2024 15:00:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50226 Mon 10 Jul 2023 11:13:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53005 Mon 06 Nov 2023 08:50:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55473 Mon 03 Jun 2024 16:16:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45427 Fri 28 Oct 2022 11:48:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52802 Fri 27 Oct 2023 14:14:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51228 Fri 25 Aug 2023 11:51:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51938 5 considered favorable). Discussion: This study demonstrated the feasibility and acceptability of a consumer-informed, non-face-to-face intensive tobacco treatment, highlighting the potential of remotely delivered technology-based CM to reduce the health impact of tobacco smoking in high-priority populations. The intervention demonstrates scale-up potential. Future studies should extend treatment into the postpartum period, utilizing new technologies to enhance CM delivery and improve counseling provision and partner support. Clinical Trial Registration: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374196, ACTRN1261800056224.]]> Fri 22 Sep 2023 13:27:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51082 Fri 18 Aug 2023 09:38:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53114 Fri 17 Nov 2023 11:41:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53185 N = 991), there was no direct relationship between passive use and mental ill-being, however user age and positive (but not negative) content appraisal were found to moderate the relationship between passive use and mental ill-being. Specifically, the relationship between passive use and mental ill-being became weaker as subjective positive appraisal increased, and it reversed to become negative at high levels of positive appraisal. Additionally, the positive relationship between passive use and mental ill-being became weaker as age of social media users increased, and the direction of this relationship became negative at the oldest ages of social media users. These results suggest that the relationship between social media use and mental ill-being is more nuanced than previous research suggests. In particular, higher amounts of passive Facebook use may have a less negative, or even a positive effect on social media users’ mental health when the content being (passively) consumed is positively appraised, or when users are older.]]> Fri 17 Nov 2023 11:24:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54828 Fri 15 Mar 2024 11:54:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52489 Fri 13 Oct 2023 10:10:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52486 Fri 13 Oct 2023 10:03:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45431 Fri 10 Mar 2023 18:06:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51558 Fri 08 Sep 2023 16:00:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51551 Fri 08 Sep 2023 15:06:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51521 Fri 08 Sep 2023 12:03:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51509 Fri 08 Sep 2023 12:03:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54686 Fri 08 Mar 2024 11:53:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54665 Fri 08 Mar 2024 10:57:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53590 PD >NG, p=0.0046). Post-hoc analysis indicated significantly higher plasma NfL levels in the T2D [12.4 (5.21) pg/mL] group than in the PD [10.2 (4.13) pg/mL] and NG [8.37 (5.65) pg/mL] groups. The relationship between diabetes status and NfL remained significant after adjusting for age, sex, BMI, HOMA-IR and physical activity (adjusted r2 = 0.271, p = 0.035). Conclusions: These results show biomarker evidence of neurodegeneration in adults at risk or with T2D. Larger sample size and longitudinal analysis are required to better understand the application of NfL in people with risk and overt T2D.]]> Fri 08 Dec 2023 15:47:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55579 Fri 07 Jun 2024 11:54:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51353 Fri 01 Sep 2023 13:35:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53516 Fri 01 Dec 2023 11:06:04 AEDT ]]>